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valproinska kiselina (za lečenje epilepsije i psihičkih oboljenja) može da uspori izlučivanje diazepama iz organizma i pojača njegovo dejstvo,Predloženi mehanizam interakcije je kompetitivno vezivanje teofilina za adenozinske receptore u mozgu. Na taj način onemogućava se farmakodinamsko dejstvo diazepama, dolazi do npr. smanjenja sedativno
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